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Cellular senescence and tumor suppression by peter d adams read online or download in secure pdf formatthese results suggest that overall the p16 ink4a gene is more responsible in inducing cellular senescence and tumor suppression in human cells interestingly the ink4aarf locus is known to be repressed by the polycomb proteins b lymphoma momlv insertion region 1 bmi1 and related family members in both human and mouse cellscellular senescence and tumor suppression editors adams peter d sedivy john m eds free preview will cover many of the recent findings in the area of senescence and cancer including chapters that discuss telomeres and senescence signals the senescent phenotype and the physiological effects of senescence including therapeutic takeuchi s takahashi a motoi n yoshimoto s tajima t et al intrinsic cooperation between p16 ink4a and p21 waf1cip1 in the onset of cellular senescence and tumor suppression in vivo cancer res 2010 70938190cellular senescence and tumor suppression it is now clear that cellular senescence is a crucial anticancer mechanism that prevents the growth of cells at risk for neoplastic transformation the stimuli that elicit a senescence response all have the potential to initiate or promote carcinogenesis

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